1170144-75-8Relevant academic research and scientific papers
Boronic acid catalyzed ene carbocyclization of acetylenic dicarbonyl compounds
Li, Meiling,Yang, Ting,Dixon, Darren J.
, p. 2191 - 2193 (2010)
The discovery and development of an efficient ene carbocyclization of 1,3-dicarbonyl compounds bearing pendent terminal alkyne substituents under 3-nitrobenzeneboronic acid catalysis is described. The reaction is efficient, easy to perform and general to a wide range of ketoester substrates.
Bronsted base/Lewis acid cooperative catalysis in the enantioselective Conia-ene reaction
Yang, Ting,Ferrali, Alessandro,Sladojevich, Filippo,Campbell, Leonie,Dixon, Darren J.
supporting information; experimental part, p. 9140 - 9141 (2009/12/06)
(Chemical Equation Presented) A mutually compatible and cooperative combination of copper(I) triflate and bifunctional 9-amino-9-deoxyepicinchona- derived urea compounds for the enantioselective Conia-ene cyclization of alkyne-tethered β-ketoester substrates is reported. The reaction is efficient, broad in scope, and easy to perform and allows access to chiral methylenecyclopentane products with high enantiocontrol. The transformation illustrates the concept of combining inactive precatalysts with inactive transition-metal-ion complexes in situ to reversibly create a catalytically active combination of the two.
