117021-15-5Relevant articles and documents
Synthesis of the marine compound (2R,5Z,9Z)-2-methoxyhexacosa-5,9-dienoic acid via a lipase-catalyzed resolution and a novel O-alkylation protocol
Kulkarni, Bheemashankar A.,Sharma, Anubha,Gamre, Sunita,Chattopadhyay, Subrata
, p. 595 - 599 (2004)
The title compound has been synthesized by a facile route starting from 4-pentyn-1-ol. The enantioselectivity was attained by a strategy involving a lipase-catalyzed acetylation of a solid-phase immobilized long chain α-hydroxy acid. Another important feature of the synthesis was the formulation of an efficient HgO-catalyzed O-methylation of the α-hydroxy acids which proceeded without any racemization. The alkylation protocol was also highly efficient for selective mono-methylation/benzylation of symmetrical diols.
Total synthesis of lembehyne A, a neuritogenic spongean polyacetylene
Murakami, Nobutoshi,Nakajima, Tatsuo,Kobayashi, Motomasa
, p. 1941 - 1943 (2001)
The first total synthesis of lembehyne A, a neuritogenic polyacetylene from a marine sponge Haliclona sp., was achieved by utilizing alkyne formation with dimethyl-1-diazo-2-oxopropylphosphonate and asymmetric reduction with Alpine-borane as the key reactions.
