117022-55-6

Basic information

• Product Name: α,α-bis(3-fluorophenyl)-4-piperidinemethanol
• Synonyms: α,α-bis(3-fluorophenyl)-4-piperidinemethanol
• CAS NO: 117022-55-6
• Molecular Weight: 303.352
• Mol File: 117022-55-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α,α-bis(3-fluorophenyl)-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-bis(3-fluorophenyl)-4-piperidinemethanol(117022-55-6)
• EPA Substance Registry System: α,α-bis(3-fluorophenyl)-4-piperidinemethanol(117022-55-6)

Safety Data

• Hazardous Substances Data: 117022-55-6(Hazardous Substances Data)

Upstream product

• 24228-40-8 N-benzyl isonipecotic acid ethyl ester 
• 1073-06-9 3-fluorobromobenzene 
• 117022-53-4 α,α-bis(3-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol 

Downstream Products

• 117023-23-1 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(3-fluorophenyl)-4-piperidinemethanol 

Relevant articles and documents

Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents

A method of treating cardiac dysfunction, the effects of histamine, and gastric secretion excesses with aryl(alkyl and alkylene)-N-[(phenoxy and phenythio)alkyl]aminoheterocyclics corresponding to the formula: STR1 wherein Ar is phenyl or substituted phenyl; R is phenyl, substituted phenyl, pyridinyl or cycloalkyl; A is hydrogen, hydroxy, cyano, amido and amino; Q is --CH2 --, --CH--, or --CHOH--; d and n are zero or one and the dotted lines form double bonds consistent with the valence of carbon; p is zero, one or two; m is one to six inclusive; B is oxygen, nitrogen, sulfur, sulfinyl or sulfonyl; z is zero or one; l is zero or one; W is hydrogen, loweralkyl, halo, nitro, loweralkoxy or hydroxy; X is hydrogen, loweralkyl, halogen, loweralkoxy or hydroxy; Y is --CH(OH)CH2 OH, --CH(OH)C(O)OH, --C(O)C(O)OH, --C(O)CH2 OH,--C(O)C(O)OCH3, --C(O)C(O)OC2 H5, --CH2 C(O)OC2 H5, --CH(OH)C(O)OCH3, --CH(OH)C(O)OC2 H5 or --C(O)CH2 OC(O)CH3 ; and the pharmaceutically acceptable salts thereof; in addition to the above methods of treatment, compounds wherein (B)z is oxygen are useful in a method of treating Gell and Coombs type 1 allergic responses in mammals.

Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.