117034-26-1Relevant articles and documents
Research on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases.
Botta,Saladino,Gentile,Summa,Nicoletti,Verri,Focher,Spadari
, p. 3603 - 3618 (2007/10/02)
The synthesis of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives 2 and 5 along with their properties as acylating agents of amines, alcohols, thiols and α-amino acids have been reported. Interestingly some of the title products revealed an inhibitory activity against the human and herpetic DNA glycosylases.
6-ALKYL-2-METHOXY-4-(3H)-PYRIMIDINONES IN THE TRANSFORMATION OF PYRIMIDINES: REGIOSPECIFIC PREPARATION, ANTITUMOR AND ANTIMICROBIAL ACTIVITY OF 4-O-ACYLATED PYRIMIDINE DERIVATIVES. NEW AGENTS FOR SELECTIVE ACYLATION OF AMINES.
Botta, Maurizio,Angelis, Francesco De,Nicoletti, Rosario,Pani, Alessandra,Marongiu, Maria Elena,Colla, Paolo La
, p. 2741 - 2744 (2007/10/02)
A high yielding synthesis of 4-O-acylated pyrimidines is presented.These products are selective reagents for amine acylation.The antitumor and antimicrobial activity of compounds 1 and 2c is also reported.