117040-04-7Relevant articles and documents
ANTIHYPERTENSIVE QUINAZOLINE DERIVATIVES
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, (2008/06/13)
Novel quinazoline compounds and antihypertensive compositions containing said compounds are disclosed; said compounds having the formula: STR1 wherein R 1 is a hydrogen atom or an alkyl group having 1-5 carbon atoms;R 2 is a group of the formula STR2 in which Y is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, an alkenyloxy group, a methylenedioxy group, a nitro group, a halogen atom, a trifluoromethyl group, an acyloxy group, a hydroxy group, an unsubstituted or substituted amino group or a condensed benzene nucleus and m is an integer of 1-3 inclusive, or a group of the formula STR3 in which X is an oxygen atom, a sulfur atom or a carbon-nitrogen double bond and Z is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, a nitro group or a halogen atom; and n is an integer of 2-3 inclusive;provided that, when R 2 is the said group STR4 n is 2 and R 1 is a hydrogen atom or, when R 2 is the said group STR5 n is 2 or 3 and R 1 is a hydrogen atom or the said alkyl group and a pharmaceutically acceptable acid addition salt thereof.