1170667-82-9Relevant articles and documents
NOVEL PRODRUGS OF METFORMIN
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Page/Page column 7, (2010/09/18)
The present invention relates to novel prodrugs of metformin, their pharmaceutically acceptable salts, pharmaceutical compositions containing the prodrugs, and methods of using the prodrugs. In particular, the present invention relates to prodrugs wherein sulfur-containing promoieties are attached to metformin to form novel bioreversible sulfenyl guanidine (N-S) prodrugs of metformin with improved oral absorption, and consequently promoted bioavailability.