1170949-99-1Relevant articles and documents
A synthesis of α-tocopherol featuring benzyne trapping by an alcohol
Knight, David W.,Qing, Xu
, p. 3534 - 3537 (2009)
A formal total synthesis of α-tocopherol, the main component of Vitamin E, has been achieved in which a central step is the intramolecular trapping of a highly substituted benzyne by an alcohol group to establish the pyran ring.
A new tactic for tocopherol synthesis using intramolecular benzyne trapping by an alcohol
Knight, David W.,Xu, Qing
, p. 647 - 672 (2017/04/10)
A formal total synthesis of (S)-α-Tocopherol, the major component of natural Vitamin E has been achieved using intramolecular benzyne trapping as a key step to form the chroman ring. The synthesis also features an efficient new method for benzotriazole N-Amination using an oxaziridine; chiral, nonracemic intermediates are generated using asymmetric dihydroxylation.
