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CAS

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1171311-06-0

3-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indol-1-yl)benzonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1171311-06-0 Structure

  • Basic information

    1. Product Name: 3-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indol-1-yl)benzonitrile
    2. Synonyms: 3-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indol-1-yl)benzonitrile
    3. CAS NO:1171311-06-0
    4. Molecular Formula:
    5. Molecular Weight: 273.337
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1171311-06-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indol-1-yl)benzonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indol-1-yl)benzonitrile(1171311-06-0)
    11. EPA Substance Registry System: 3-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indol-1-yl)benzonitrile(1171311-06-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1171311-06-0(Hazardous Substances Data)

1171311-06-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1171311-06-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,1,3,1 and 1 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1171311-06:
(9*1)+(8*1)+(7*7)+(6*1)+(5*3)+(4*1)+(3*1)+(2*0)+(1*6)=100
100 % 10 = 0
So 1171311-06-0 is a valid CAS Registry Number.

1171311-06-0Downstream Products

1171311-06-0Relevant articles and documents

Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2)

Spindler, Anna,Stefan, Katja,Wiese, Michael

, p. 6121 - 6135 (2016)

The breast cancer resistance protein (ABCG2) transports chemotherapeutic drugs out of cells, which makes it a major player in mediating multidrug resistance (MDR) of cancer cells. To overcome this mechanism, inhibitors of ABCG2 can be used. Only a few potent and selective ABCG2 inhibitors have been discovered, i.e., fumitremorgin C (FTC), Ko143, and the alkaloid harmine, which contain a tetrahydro-β-carboline or β-carboline backbone, respectively. However, toxicity and or instability prevent their use in vivo. Therefore, there is a need for further potent inhibitors. We synthesized and pharmacologically investigated 37 tetrahydro-β-carboline derivatives. The inhibitory activity of two compounds (51, 52) is comparable to that of Ko143, and they are selective for ABCG2 over ABCB1. Furthermore, they are able to reverse the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity. The cytotoxicity data show that their inhibitory effect is substantially higher than their toxicity.

ANTIBIOTIC TETRAHYDRO-BETA-CARBOLINE DERIVATIVES

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Page/Page column 46-47, (2009/10/09)

Disclosed are compounds of Formula (I), pharmaceutical compositions comprising Formula (I) and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatmen

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