117139-60-3Relevant academic research and scientific papers
Highly enantioselective direct organocatalytic α-chlorination of ketones
Marigo, Mauro,Bachmann, Stephan,Halland, Nis,Braunton, Alan,Jorgensen, Karl Anker
, p. 5507 - 5510 (2004)
A C2-symmetric diamine serves as the organocatalyst in an asymmetric α-chlorination reaction of simple ketones (e.g., cyclohexanone, diethyl ketone). Optically active α-chloroketones are formed with excellent enantioselectivities using N-chlorosuccinimide (NCS) as the chlorine source (see scheme). These products have broad synthetic utility, in particular for pharmaceutical applications.
