117151-82-3Relevant academic research and scientific papers
2-(N-SUBSTITUTED PIPERAZINYL) STEROID DERIVATIVES
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Page/Page column 56; 97-98, (2010/06/17)
Novel chemical agents of Formula I are described herein. More specifically, 2-(N-substituted piperazinyl) pregnane and 2-(N-substituted piperazinyl) androstane derivatives exhibiting cytotoxicity on a variety of cancer cell lines are disclosed herein. (I)
STEREOSELECTIVE REDUCTION OF C-2 SUBSTITUTED STEROID C-3 KETONES WITH LITHIUM TRIS-(R,S-1,2-DIMETHYLPROPYL)-BOROHYDRIDE AND SODIUM BOROHYDRIDE
Templeton, John F.,Kumar, V. P. Sashi,Gupta, R. K.,Friesen, Anne M.
, p. 339 - 346 (2007/10/02)
The effect of C-2 substitution on the stereoselective reduction of steroid C-3 ketones with lithium tris(R,S-1,2-dimethylpropyl)-borohydride and sodium borohydride was investigated.The C-2 mono- and di-substituted chloro and methyl derivatives were predominantly reduced to one of the epimeric alcohols.The 2α-chloro and 2α-methyl derivatives of 17β-acetoxy-5α-androstan-3-one undergo stereoselective reduction with lithium tris (R,S-1,2-dimethylpropyl)-borohydride to the axial (3α) alcohol as observed in the unsubstituted compound, whereas sodium borohydride gives predominantly the equatorial (3β) alcohol.The 2β-chloro, 2β-methyl, 2,2-dichloro, and 2,2-dimethyl derivatives are reduced predominantly to the equatorial (3β) alcohol by both reagents.
