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117174-84-2

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117174-84-2 Usage

Description

1-(3-Chloro-4-methylphenyl)-2-thiourea, also known as CMPTU, is a chemical compound with the molecular formula C8H8ClN3S. It is a thiourea derivative that is used in research and pharmaceutical purposes. CMPTU is known for its potential as a thyroxine mimetic, an inhibitor of various enzymes, and for its anti-thyroid and anti-neoplastic properties. 1-(3-CHLORO-4-METHYLPHENYL)-2-THIOUREA's ability to interact with thyroid hormone receptors makes it a promising candidate for therapeutic applications in the treatment of thyroid disorders and cancer.

Uses

Used in Pharmaceutical Research:
CMPTU is used as a thyroxine mimetic for studying the effects of thyroid hormones on various biological processes. Its interaction with thyroid hormone receptors aids in understanding the molecular mechanisms underlying thyroid disorders and the development of potential therapeutic agents.
Used in Enzyme Inhibition:
CMPTU is used as an enzyme inhibitor in research to investigate its potential to modulate the activity of various enzymes. This can help in understanding the role of these enzymes in disease processes and the development of enzyme-targeted therapies.
Used in Thyroid Disorder Treatment:
CMPTU is used as a potential therapeutic agent for the treatment of thyroid disorders. Its ability to interact with thyroid hormone receptors may help in regulating thyroid hormone levels and alleviating symptoms associated with these disorders.
Used in Cancer Therapy:
CMPTU is used as an anti-neoplastic agent in research for its potential to inhibit the growth and progression of cancer cells. Its interaction with thyroid hormone receptors and enzyme inhibition properties may contribute to its anti-cancer effects.
Used in Antibacterial Applications:
CMPTU is used as an antibacterial agent in research for its potential to inhibit the growth of bacteria. Its ability to target specific bacterial enzymes or pathways may contribute to its antibacterial activity.
Used in Antiviral Applications:
CMPTU is used as an antiviral agent in research for its potential to inhibit viral replication and infection. Its interaction with host enzymes or receptors may help in preventing viral entry or replication, offering a potential therapeutic approach against viral diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 117174-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,1,7 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117174-84:
(8*1)+(7*1)+(6*7)+(5*1)+(4*7)+(3*4)+(2*8)+(1*4)=122
122 % 10 = 2
So 117174-84-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2S/c1-5-2-3-6(4-7(5)9)11-8(10)12/h2-4H,1H3,(H3,10,11,12)

117174-84-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-Chloro-4-methylphenyl)-2-thiourea

1.2 Other means of identification

Product number -
Other names (3-chloro-4-methylphenyl)thiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:117174-84-2 SDS

117174-84-2Relevant articles and documents

Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase

Zhu, Junsheng,Han, Le,Diao, Yanyan,Ren, Xiaoli,Xu, Minghao,Xu, Liuxin,Li, Shiliang,Li, Qiang,Dong, Dong,Huang, Jin,Liu, Xiaofeng,Zhao, Zhenjiang,Wang, Rui,Zhu, Lili,Xu, Yufang,Qian, Xuhong,Li, Honglin

, p. 1123 - 1139 (2015/03/04)

Human dihydroorotate dehydrogenase (HsDHODH) is a flavin-dependent mitochondrial enzyme that has been certified as a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases. On the basis of lead compound 4, which was previously identified as potential HsDHODH inhibitor, a novel series of thiazole derivatives were designed and synthesized. The X-ray complex structures of the promising analogues 12 and 33 confirmed that these inhibitors bind at the putative ubiquinone binding tunnel and guided us to explore more potent inhibitors, such as compounds 44, 46, and 47 which showed double digit nanomolar activities of 26, 18, and 29 nM, respectively. Moreover, 44 presented considerable anti-inflammation effect in vivo and significantly alleviated foot swelling in a dose-dependent manner, which disclosed that thiazole-scaffold analogues can be developed into the drug candidates for the treatment of rheumatoid arthritis by suppressing the bioactivity of HsDHODH.

Synthesis of some new 4-{2-[(aryl)amino]-1,3-thiazol-4-yl}benzene-1,2-diols as possible antibacterial and antifungal agents

Narayana,Ashalatha,Vijaya Raj,Suchetha Kumari

, p. 1381 - 1389 (2007/10/03)

Some new 4-{2-[(aryl) amino]-1,3-thiazol-4-yl}benzene-1,2-diols are prepared and characterized by spectral analysis. The newly prepared compounds are studied for their antibacterial and antifungal activity. Interestingly, almost all the compounds are found to possess promising antibacterial and antifungal activity against all tested microorganisms. Copyright Taylor & Francis Group, LLC.

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

Rasmussen, C. R.,Villani, F. J.,Weaner, L. E.,Reynolds, B. E.,Hood, A. R.,et al.

, p. 456 - 459 (2007/10/02)

An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N'-benzoylthioureas with 5percent aqueous sodium hydroxide.Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g. 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.

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