1171775-66-8Relevant academic research and scientific papers
Mycobacterium tuberculosis Decaprenylphosphoryl-β- d -ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity
Borthwick, Jennifer A.,Alemparte, Carlos,Wall, Ian,Whitehurst, Benjamin C.,Argyrou, Argyrides,Burley, Glenn,De Dios-Anton, Paco,Guijarro, Laura,Monteiro, Maria Candida,Ortega, Fatima,Suckling, Colin J,Pichel, Julia Castro,Cacho, Monica,Young, Robert J.
, p. 2557 - 2576 (2020/03/31)
Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) is an essential enzyme in Mycobacterium tuberculosis and has recently been studied as a potential drug target, with inhibitors progressing to clinical studies. Here we describe the identification of a n
HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE
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Page/Page column 43, (2010/12/29)
The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R1 and R2 independently represents a group such as a hydrogen atom or a halogen atom; R3 represents a group such as a hydrogen atom; each of R4 and R5 independently represents a group such as a hydrogen atom, a halogen atom or a C1-4 alkyl group; each of R6 and R7 independently represents a hydrogen atom or a C1-4 alkyl group; X represents a group such as a C3-10 cycloalkyl group, C6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as -CO-, -O- or -NRa-, and Ra represents a group such as a hydrogen atom or a C1-4 alkyl group.
