1171817-09-6Relevant articles and documents
Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy
Iino, Tomoharu,Hashimoto, Noriaki,Sasaki, Kaori,Ohyama, Sumika,Yoshimoto, Riki,Hosaka, Hideka,Hasegawa, Takuro,Chiba, Masato,Nagata, Yasufumi,Eiki, Jun-ichi,Nishimura, Teruyuki
supporting information; experimental part, p. 3800 - 3809 (2009/10/02)
The optimization of our lead GK activator 2a to 3-[(1S)-2-hydroxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide (6g), a potent GK activator with good oral availability, is described, including to uncouple the relationship betwe