1171848-48-8Relevant articles and documents
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity
Tapadar, Subhasish,He, Rong,Luchini, Doris N.,Billadeau, Daniel D.,Kozikowski, Alan P.
, p. 3023 - 3026 (2009)
A series of hydroxamic acid based histone deacetylase inhibitors 6-15, containing an isoxazole moiety adjacent to the Zn-chelating hydroxamic acid, is reported herein. Some of these compounds showed nanomolar activity in the HDAC isoform inhibitory assay