1171891-07-8

Basic information

• Product Name: 5-Phenyl-3-pyridinyl boronic acid, pinacol ester
• Synonyms: 5-Phenyl-3-pyridinyl boronic acid, pinacol ester;5-Phenylpyridine-3-boronic acid pinacol ester
• CAS NO: 1171891-07-8
• Molecular Formula: C₁₇H₂₀BNO₂
• Molecular Weight: 299.17248
• Mol File: 1171891-07-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• PKA: 4.84±0.22(Predicted)
• CAS DataBase Reference: 5-Phenyl-3-pyridinyl boronic acid, pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Phenyl-3-pyridinyl boronic acid, pinacol ester(1171891-07-8)
• EPA Substance Registry System: 5-Phenyl-3-pyridinyl boronic acid, pinacol ester(1171891-07-8)

Safety Data

• Hazardous Substances Data: 1171891-07-8(Hazardous Substances Data)

Usage

General Description

5-Phenyl-3-pyridinyl boronic acid, pinacol ester is a chemical compound with the molecular formula C18H23BN2O2. It is a boronic acid ester derivative that is commonly used in organic synthesis and medicinal chemistry. 5-Phenyl-3-pyridinyl boronic acid, pinacol ester is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. It acts as a versatile cross-coupling reagent in the Suzuki-Miyaura reaction, allowing for the formation of carbon-carbon bonds. Additionally, it has been studied for its potential use in the treatment of cancer and other diseases due to its ability to target specific biological pathways. Overall, 5-Phenyl-3-pyridinyl boronic acid, pinacol ester is a valuable chemical compound with various applications in the field of chemistry and medicine.

InChI:InChI=1S/C17H20BNO2/c1-16(2)17(3,4)21-18(20-16)15-10-14(11-19-12-15)13-8-6-5-7-9-13/h5-12H,1-4H3

Upstream product

• 1008-88-4 3-phenylpyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1428521-63-4 3-cyclopropyl-6-fluoro-2-(5-phenylpyridin-3-yl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Enzyme-like Supramolecular Iridium Catalysis Enabling C?H Bond Borylation of Pyridines with meta-Selectivity

The use of secondary interactions between substrates and catalysts is a promising strategy to discover selective transition metal catalysts for atom-economy C?H bond functionalization. The most powerful catalysts are found via trial-and-error screening due to the low association constants between the substrate and the catalyst in which small stereo-electronic modifications within them can lead to very different reactivities. To circumvent these limitations and to increase the level of reactivity prediction in these important reactions, we report herein a supramolecular catalyst harnessing Zn???N interactions that binds to pyridine-like substrates as tight as it can be found in some enzymes. The distance and spatial geometry between the active site and the substrate binding site is ideal to target unprecedented meta-selective iridium-catalyzed C?H bond borylations with enzymatic Michaelis–Menten kinetics, besides unique substrate selectivity and dormant reactivity patterns.

Pyrrolopyrimidines and Pyrrolopyridines

Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.