1171891-35-2

Basic information

• Product Name: 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ol
• Synonyms: 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ol;5-hydroxypridine-3-boronic acid pinacol ester;(5-hydroxy-3-pyridyl)boronic acid;5-Hydroxypyridine-3-boronic acid pinacol ester;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinol
• CAS NO: 1171891-35-2
• Molecular Formula: C₁₁H₁₆BNO₃
• Molecular Weight: 221.06064
• Mol File: 1171891-35-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 414.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.16±0.10(Predicted)
• CAS DataBase Reference: 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ol(1171891-35-2)
• EPA Substance Registry System: 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ol(1171891-35-2)

Safety Data

• Hazardous Substances Data: 1171891-35-2(Hazardous Substances Data)

Usage

General Description

5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ol is a chemical compound with a molecular formula of C12H16BNO2. It is a boronic ester derivative commonly used in organic synthesis as a reagent for Suzuki-Miyaura cross-coupling reactions. The compound contains a pyridin-3-ol moiety attached to a boronic ester group, which makes it a valuable building block in pharmaceutical and agrochemical research. The presence of the boronic ester group allows for the compound to act as a ligand in transition metal-catalyzed transformations, making it a versatile tool for the construction of complex molecules. Additionally, the tetramethyl substitution pattern enhances the stability and reactivity of the compound, making it a valuable reagent in organic chemistry.

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1605327-44-3 (S)-2-(1-((6-amino-5-(5-hydroxypyridin-3-yl)pyrimidin-4-yl)amino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one 

Relevant articles and documents

PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS

New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).