1171900-40-5

Upstream product

• 626-55-1 3-Bromopyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 13534-89-9 2,3-dibromopyridine 

Relevant academic research and scientific papers

Syntheses of Benzofuranoquinolines and Analogues via Photoinduced Acceptorless Dehydrogenative Annulation of o-Phenylfuranylpyridines

A strategy for the syntheses of benzofuranoquinolines and its analogues via the irradiation of o-phenylfuranyl/thienylpyridines/pyrimidines in DCM with UV light at rt under an argon atmosphere is described. The mechanism of this reaction through the proce

Synthesis of 6-phenylbenzo[h]quinolinesviaphotoinduced dehydrogenative annulation of (E)-2-phenyl-3-styrylpyridines

A concise and environmentally friendly protocol was developed for the synthesis of 6-phenylbenzo[h]quinolines. 6-Phenylbenzo[h]quinolines were obtained in good yieldsviairradiation of (E)-2-phenyl-3-styrylpyridines with a 254 nm UV light (64 W) in EtOH under an argon atmosphere in the presence of TFA. The reaction is a dehydrogenative annulation reaction that proceeds through 6π-electrocyclization, a [1,5]-H shift, 1,3-enamine tautomerization, and elimination of a hydrogen molecule to afford 6-phenylbenzo[h]quinolines. The described protocol not only avoids the usage of a transition metal catalyst and an oxidant but also has the advantages of high atom efficiency and mild reaction conditions.

Palladium-catalyzed highly regioselective 2-arylation of 2,x-dibromopyridines and its application in the efficient synthesis of a 17β-HSD1 inhibitor

2,3- and 2,5-Dibromopyridines reacted with arylboronic acids, catalyzed by Pd(OAc)2/PPh3 in the presence of K2CO 3 in CH3CN/MeOH (2:1) at 50 C for 24 h, to afford 2-arylpyridines in good to high yield

Direct C-H arylation of electron-deficient heterocycles with arylboronic acids

A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.

Monoarylation of dibromoarenes by simple palladium catalyst systems: Efficient synthesis of bromobiaryls from dibromoarenes and arylboronic acids

The Pd/C/Ph3P- and Pd(PPh3)4/Ph 3P-catalyzed cross-couplings of dibromoarenes with arylboronic acids to form bromobiaryls in good to excellent yields are described. Our study showed that readily available Pd/C/P