1171997-71-9Relevant academic research and scientific papers
Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography
Kimura, Yasuaki,Yamatsugu, Kenzo,Kanai, Motomu,Echigo, Noriko,Kuzuhara, Takashi,Shibasaki, Masakatsu
, p. 3205 - 3208 (2009)
A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu an
Design and synthesis of resin-conjugated Tamiflu analogs for affinity chromatography
Kimura, Yasuaki,Yamatsugu, Kenzo,Kanai, Motomu,Echigo, Noriko,Kuzuhara, Takashi,Shibasaki, Masakatsu
experimental part, p. 588 - 594 (2010/08/07)
Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu.
