117201-52-2

Upstream product

• 350-90-3 (Z/E)-2-fluoro-3-phenylprop-2-enoic acid 

Downstream Products

• 1247703-18-9 2-(1-fluoro-2-phenylvinyl)-5-nitrobenzo[d]oxazole 
• 1421441-05-5 (Z)-1-(3,4-dimethoxyphenyl)-2-fluoro-3-phenyl-2-propen-1-one 
• 117040-11-6 (Z)-1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-fluoro-3-phenyl-propenone; hydrochloride 

Relevant academic research and scientific papers

BENZOXAZOLES FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

Compounds of formula (I), wherein R1, R2, R3, X and n are as defined herein, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.

PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES

Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.