117211-21-9

Basic information

• Product Name: N-[1-(3-Chlorphenyl)benzyl]urea
• Synonyms: N-[1-(3-Chlorphenyl)benzyl]urea;1-((3-chlorophenyl)(phenyl)methyl)urea
• CAS NO: 117211-21-9
• Molecular Formula: C₁₄H₁₃ClN₂O
• Molecular Weight: 261.72676
• Mol File: 117211-21-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 413.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 12.68±0.46(Predicted)
• CAS DataBase Reference: N-[1-(3-Chlorphenyl)benzyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(3-Chlorphenyl)benzyl]urea(117211-21-9)
• EPA Substance Registry System: N-[1-(3-Chlorphenyl)benzyl]urea(117211-21-9)

Safety Data

• Hazardous Substances Data: 117211-21-9(Hazardous Substances Data)

Usage

Description

N-[1-(3-Chlorphenyl)benzyl]urea is a urea derivative chemical compound, characterized by its white crystalline solid appearance and a molecular formula of C15H13ClN2O. It has been the subject of research for its potential as an antidiabetic agent, with studies suggesting its capacity to reduce blood glucose levels. Furthermore, it has demonstrated insecticidal properties, positioning it as a candidate for use in agriculture against pests. N-[1-(3-Chlorphenyl)benzyl]urea's multifaceted biological activities have garnered interest in both pharmaceutical and agricultural sectors.

Uses

Used in Pharmaceutical Industry:
N-[1-(3-Chlorphenyl)benzyl]urea is used as an antidiabetic agent for its potential to lower blood glucose levels, offering a new avenue for the treatment of diabetes.
Used in Agricultural Industry:
N-[1-(3-Chlorphenyl)benzyl]urea is used as an insecticide for its bioactivity against agricultural pests, providing a potential solution for pest control in farming.

Upstream product

• 55095-14-2 [1-phenyl-1-(3-chlorophenyl)methyl]amine 
• 57-13-6 urea 
• 160807-84-1 N,N'-di[(3-chlorophenyl)phenylmethyl]urea 
• 917-61-3 sodium isocyanate 

Downstream Products

• 160807-84-1 N,N'-di[(3-chlorophenyl)phenylmethyl]urea 

Relevant articles and documents

The determination of enantiomer composition of 1‐((3‐chlorophenyl)‐(phenyl)methyl) amine and 1‐((3‐chlorophenyl)(phenyl)‐methyl) urea (galodif) by nmr spectroscopy, chiral hplc, and polarimetry

For the first time, a method for enantiomer resolution of the anticonvulsant Galodif (1‐((3‐chlorophenyl)(phenyl)methyl) urea) by chiral HPLC was developed, whereas the enantiomeric composition of 1‐((3‐chlorophenyl)(phenyl) methyl) amine—precursor in Galodif synthesis—cannot be resolved by this method. However, starting 1‐((3‐chlorophenyl)(phenyl)methyl) amine quantitatively forms diastereomeric N‐((3‐chlorophenyl)(phenyl)methyl)‐1‐ camphorsulfonamides in reaction with chiral (1R)‐(+)‐ or (1S)‐(?)‐camphor‐10‐ sulfonyl chlorides. The diastereomeric ratio of obtained camphorsulfonamides can be easily determined by NMR1H and13C spectroscopy. The DFT calculations of specific rotation of Galodif enantiomers showed good agreement with experimental data. The absolute configuration of enantiomers was proposed for the first time.

QUANTITATUVE RELATIONSHIP BETWEEN ANTICONVULSANT ACTIVITY IN N-BENZHYDRYLAMIDES AND N-BENZHYDRYLURAES, THEIR STRUCTURES, AND (13)C NMR SPECTRA

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