117238-42-3Relevant articles and documents
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors
Cheng, Jie-Fei,Chen, Mi,Wallace, David,Tith, Souvothy,Haramura, Masayuki,Liu, Bin,Mak, Chi Ching,Arrhenius, Thomas,Reily, Sean,Brown, Steven,Thorn, Vicki,Harmon, Charles,Barr, Rick,Dyck, Jason R. B.,Lopaschuk, Gary D.,Nadzan, Alex M.
, p. 1517 - 1525 (2006)
The discovery and structure-activity relationship of first-generation small-molecule malonyl-CoA decarboxylase (MCD; CoA = coenzyme A) inhibitors are reported. We demonstrated that MCD inhibitors increased malonyl-CoA concentration in the isolated working