117249-18-0

Upstream product

• 72-87-7 N-acetyl-D-galactosamine 
• 131-48-6 N-Acetylneuraminic acid 
• 117177-11-4 Benzyl-O-(5-acetamido-3,5-didesoxy-D-glycero-α-D-galacto-2-nonulopyranosylonsaeure)-(2->3)-O-<(2,6-di-O-(α-(2)H2)benzyl-β-D-galactopyranosyl>-(1->3)-2-acetamido-4,6-di-O-(α-(2)H2)benzyl-2-desoxy-β-D-galactopyranosid 
• 117177-11-4 Benzyl-O-(5-acetamido-3,5-didesoxy-D-glycero-β-D-galacto-2-nonulopyranosylonsaeure)-(2->3)-O-<(2,6-di-O-(α-(2)H2)benzyl-β-D-galactopyranosyl>-(1->3)-2-acetamido-4,6-di-O-(α-(2)H2)benzyl-2-desoxy-β-D-galactopyranosid 
• 20972-29-6 D-galactose-β-1,3-N-acetyl-galactosamine 

Downstream Products

• 117773-04-3 O-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic-acid)-(2-3)-O-β-D-galactopyranosyl-(1-3)-2-acetamido-2-deoxy-β-D-galactopyranose 

Relevant academic research and scientific papers

Ein Multienzymsystem zur Eintopfsynthese des Sialyl-T-Antigens

Stichworte: Enzymkatalyse * β-Galactosidase * Oligosaccharidsynthesen * Sialyltransferase * T-Antigen

The use of porcine liver (2->3)-α-sialyltransferase in the large-scale synthesis of α-Neup5Ac-(2->3)-β-D-Galp-(1->3)-D-GlcpNAc, the epitope of the tumor-associated carbohydrate antigen CA 50

α-Neup5Ac-(2->3)-β-D-Galp-(1->3)-D-GlcpNAc (2) and, α-Neup5Ac-(2->3)-β-D-Galp-(1->3)-β-D-GlcpNAcOMBn were prepared on a large scale by the action of β-D-Galp-(1->3)-D-GalpNAc (2->3)-α-sialyltransferase (partially purified from porcine liver) on β-D-Galp-(1->3)-D-GlcpNAc and β-D-Galp-(1->3)-β-D-GlcpNAcOMBn, respectively.The trisaccharide 2 is the epitope of the tumor-associated carbohydrate antigen CA 50, highly expressed in human pancreatic adenocarcinoma.