1172590-11-2Relevant articles and documents
ASCAROSIDE DERIVATIVES AND METHODS OF USE
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, (2020/12/07)
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).
COMPOSITIONS AND METHODS FOR ASCAROSIDE MODIFICATION OF MAMMALIAN MICROBIOTA
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, (2020/12/29)
Described herein are composition of ascarosides, methods of using them, and the like for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for modifying a microbiome of a patient (e.g., for treatment of gut microbiome dysfunction).
Ascaroside activity in Caenorhabditis elegans is highly dependent on chemical structure
Hollister, Kyle A.,Conner, Elizabeth S.,Zhang, Xinxing,Spell, Mark,Bernard, Gary M.,Patel, Pratik,De Carvalho, Ana Carolina G.V.,Butcher, Rebecca A.,Ragains, Justin R.
, p. 5754 - 5769 (2013/09/12)
The nematode Caenorhabditis elegans secretes ascarosides, structurally diverse derivatives of the 3,6-dideoxysugar ascarylose, and uses them in chemical communication. At high population densities, specific ascarosides, which are together known as the dau
Improved synthesis of an ascaroside pheromone controlling dauer larva development in caenorhabditis elegans
Martin, Rene,Schaefer, Tina,Theumer, Gabriele,Entchev, Eugeni V.,Kurzchalia, Teymuras V.,Knoelker, Hans-Joachim
experimental part, p. 3488 - 3492 (2010/03/02)
Using an efficient Wacker oxidation as a key step, we describe a significantly improved synthesis of the dauer-promoting ascaroside 2 for biological studies of the novel sterol ring methylase STRM-1.
An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations
Butcher, Rebecca A.,Ragains, Justin R.,Clardy, Jon
supporting information; experimental part, p. 3100 - 3103 (2009/12/09)
In Caenorhabdltls elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, "nonaging" dauer larval stage. Here, using activity-guided fractionation