1172612-51-9Relevant articles and documents
Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl) pyrimidines
Sharma, Sameer,Kedrowski, Jeffrey,Rook, Jerri M.,Smith, Randy L.,Jones, Carrie K.,Rodriguez, Alice L.,Conn, P. Jeffrey,Lindsley, Craig W.
scheme or table, p. 4103 - 4106 (2010/02/17)
We describe the synthesis and SAR of a series of analogues of the mGlu5 partial antagonist 5-(phenylethynyl)pyrimidine. New molecular switches are identified that modulate the pharmacological activity of the lead compound. Slight structural modifications