1172624-01-9Relevant academic research and scientific papers
Chemically-selective surface glyco-functionalization of liposomes through Staudinger ligation
Zhang, Hailong,Ma, Yong,Sun, Xue-Long
, p. 3032 - 3034 (2009)
An efficient and chemoselective liposome surface glyco-functionalization method has been developed based on Staudinger ligation, in which the carbohydrate derivative carrying an azide spacer is conjugated onto the surface of preformed liposomes bearing a
A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: Synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies
Bhardwaj, Atul,Huang, Zhangjian,Kaur, Jatinder,Yang, Fenghua,Seubert, John M.,Knaus, Edward E.
, p. 2769 - 2774 (2013)
1-(7-Azabenzobicyclo[2.2.1]heptane)diazen-1-ium-1,2-diolate (16) was designed with the expectation that it would act as a dual nitric oxide (NO) and nitroxyl (HNO) donor that is not carcinogenic or genotoxic. Compound 16, with a suitable half-life (17.8 min) in PBS at pH 7, released NO (19%) and HNO (22%) during a 2 h incubation in PBS at pH 7. In addition, compound 16 exhibited a significant in vitro positive inotropic effect, increased the rates of contraction and relaxation, and increased coronary flow rate, but did not induce a chronotropic effect. Furthermore, compound 16 (13.7 mg kg-1, po dose) provided a significant reduction in the blood pressure of mice up to 3 h post-drug administration. All these data suggest that compound 16 constitutes an attractive 'lead-compound' that could have potential applications to treat cardiovascular disease(s) such as congestive heart failure.
Stoichiometric Nitroxyl Photorelease Using the (6-Hydroxy-2-naphthalenyl)methyl Phototrigger
Zhou, Yang,Cink, Ruth B.,Seed, Alexander J.,Simpson, M. Cather,Sampson, Paul,Brasch, Nicola E.
supporting information, p. 1054 - 1057 (2019/05/16)
The design and synthesis of a photoactivatable HNO donor incorporating the (6-hydroxynaphthalen-2-yl)methyl (6,2-HNM) photocage coupled to the trifluoromethanesulfonamidoxy analogue of the well-established HNO generator Piloty's acid is described. The photoactive HNO donor stoichiometrically generates HNO (～98%) at neutral pH conditions, and evidence for concerted C-O and N-S bond cleavage was obtained. The methanesulfonamidoxy analogue primarily undergoes undesired N-O bond cleavage.
Rapid and selective nitroxyl (HNO) trapping by phosphines: Kinetics and new aqueous ligations for HNO detection and quantitation
Reisz, Julie A.,Zink, Charles N.,King, S. Bruce
experimental part, p. 11675 - 11685 (2011/10/02)
Recent studies distinguish the biological and pharmacological effects of nitroxyl (HNO) from its oxidized/deprotonated product nitric oxide (?NO), but the lack of HNO detection methods limits the understanding its in vivo mechanisms and the identification
