1172627-12-1Relevant articles and documents
Organocatalytic enantioselective olefin aminofluorination
Appayee, Chandrakumar,Brenner-Moyer, Stacey E.
supporting information; scheme or table, p. 3356 - 3359 (2010/11/03)
(Equation Presented). Chiral β-fluoroamines are increasingly prevalent in medicinal compounds, but there are few efficient methods to access them from achiral starting materials. To address this, a multicomponent organocascade reaction was developed in which chiral α-fluoro-β-amino aldehydes were generated in a single flask from achiral α,β-unsaturated aldehydes (2), using catalyst 12a. Conversions up to 85%, drs up to 98:2 and ees up to 99% of the corresponding alcohol (9) were achieved in this reaction.
