117267-39-7

Basic information

• Product Name: N-[(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methyl]methanesulfonamide
• Synonyms: N-[(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methyl]methanesulfonamide
• CAS NO: 117267-39-7
• Molecular Formula: C18H16ClN5O2S
• Molecular Weight: 401.86994
• Mol File: 117267-39-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 629.3°Cat760mmHg
• Flash Point: 334.4°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 9.47E-16mmHg at 25°C
• Refractive Index: 1.723
• CAS DataBase Reference: N-[(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methyl]methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methyl]methanesulfonamide(117267-39-7)
• EPA Substance Registry System: N-[(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methyl]methanesulfonamide(117267-39-7)

Safety Data

• Hazardous Substances Data: 117267-39-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H16ClN5O2S/c1-27(25,26)21-11-17-23-22-16-10-20-18(12-5-3-2-4-6-12)14-9-13(19)7-8-15(14)24(16)17/h2-9,21H,10-11H2,1H3

Upstream product

• 117267-35-3 (methanesulfonamido)acethydrazide 
• 4547-02-8 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione 

Relevant articles and documents

POTENTIAL ANXIOLYTICS AND HYPNOTICS: 1-(ALKANESULFONAMIDOALKYL)-6-ARYL-8-HALOGENO-s-TRIAZOLO-1,4-BENZODIAZEPINES AND RELATED COMPOUNDS

7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-thione and its 5-(2-chlorophenyl) and 7-bromo-5-(2-chlorophenyl) analogoues were reacted with N-(methanesulfonyl)- and N-(ethanesulfonyl)glycine and -alanine hydrazides (X-XIII) in boiling butanol to give the title compounds Iabc-IVabc.The alanine-derived substances IIIabc and IVabc were characterized by 1H NMR spectra as mixtures of two diastereoisomers.Similar reactions of 5-methylimidazole-4-carboxylic acid hydrazide (XIV) gave the s-triazolo-1,4-benzodiazepines Vabc together with their ring-opened precursors XVI and XVII.The compounds prepared showed the activity profile of the anxiolytic and hypnotic 4H-s-triazolo-1,4-benzodiazepine derivatives.