117290-18-3

Upstream product

• 3144-09-0 methanesulfonamide 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant academic research and scientific papers

PD-1/PD-L1 INHIBITORS

Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

New process for the synthesis of acylsulfonamides derivatives

The present invention refers to the treatment of Alzheimer's diseases such as necessary or useful as an intermediate for pharmaceuticals for merging, joining a selectively N - acylated reaction include specific method relates to useful as intermediates for the synthesis of the opinion phone which will know probably the id, carboxyl group activated carboxyl group number are previous method using a long time after the opinion phone which will know probably the id [...] and activate the heating reacting synthesizing either harsh reaction conditions, which does not direct use of organic acid anhydride [...] shape after reacting fatal door perfect point of which the number in order to solve gun [su [su] [ceyn] 5 to 25 degrees [...] organic base and organic acid [sep [sep] city mild reaction conditions in the presence of tree also reacting time 1 in high yield and purity can be short response times in the inside and outside of the opinion phone which will know probably the id number number [...] method by a high pressure liquid coolant, medicinal and their need in the field of power generation significantly contribute to pathogenic zymotic techniques and related intermediates are disclosed. (by machine translation)

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

A challenge associated with drug design is the development of selective inhibitors of proteases (serine or cysteine) that exhibit the same primary substrate specificty, that is, show a preference for the same P1 residue. While these proteases have similar active sites, nevertheless there are subtle differences in their S and S' subsites which can be exploited. We describe herein for the first time the use of functionalized sulfonamides as a design and diversity element which, when coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold yields potent, time-dependent inhibitors of the serine proteases human leukocyte elastase (HLE), proteinase 3 (PR 3) and cathepsin G(Cat G). Our preliminary findings suggest that (a) appending to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold recognition and diversity elements that interact with both S and S' subsites of a target protease may result in optimal enzyme selectivity and potency and, (b) functionalized sulfonamides constitute a powerful design and diversity element with low intrinsic chemical reactivity and potentially wide applicability. Copyright