1172995-29-7Relevant academic research and scientific papers
Regioselective synthesis and bioactivity of new 5-amino-6- Arylamino-pyrazolo[3,4-d]-pyrimidin-4(5H)-one derivatives
Wang, Hong-Qing,Zhou, Wei-Ping,Wang, Yu-Yuan,Lin, Can-Rong,Liu, Zhao-Jie
experimental part, p. 256 - 260 (2009/06/21)
A novel approach to regioselective synthesis of new 5-amino-6-arylamino-1H- pyrazolo[3,4-d]pyrimi- din-4(5H)-one 5 derivatives via a tandem aza-wittig and annulation reaction of iminophosphorance 2, aromatic isocyanates and hydrazine in 69.6-94.7% isolated yields is reported. The compound 5 reacted with triethyl orthoformate to give compound 6 in good yield (65.8-82.8%). Their structure was clearly confirmed by spectroscopy data (IR, 1H NMR, MS, elemental analysis) and the results of preliminary bioassay indicated that compounds 5 and 6 possess high antifungal activity against Botrytis cinerea Pers and Sclerotinia sclerotiorum, and compound 5h showed 100, 96.4, and 90.2% inhibitory rate to Botrytis cinerea Pers, Pyricularia oryzae, and Sclerotinia sclerotiorum at the concentration of 50 mg/L. The antifungal activities of compound 6 were generally higher than those of compound 5.
