1173022-16-6 Usage
Description
The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 μM). It inhibits the related CCR1 receptor with an IC50 value of 17.8 μM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 μM, respectively. RS 102895 prevents chemotaxis of THP-1 cells (IC50 = 1.7 μM) when MCP-1 is presented as a chemoattractant.
Uses
RS 102895 Hydrochloride is used as a leukocyte infiltrate marker for rosacea diagnosis.
Check Digit Verification of cas no
The CAS Registry Mumber 1173022-16-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,3,0,2 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1173022-16:
(9*1)+(8*1)+(7*7)+(6*3)+(5*0)+(4*2)+(3*2)+(2*1)+(1*6)=106
106 % 10 = 6
So 1173022-16-6 is a valid CAS Registry Number.
