117312-02-4

Basic information

• Product Name: 5'-benzoyl-2',3'-dideoxyinosine
• CAS NO: 117312-02-4
• Molecular Weight: 340.338
• Mol File: 117312-02-4.mol

Chemical Properties

• CAS DataBase Reference: 5'-benzoyl-2',3'-dideoxyinosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-benzoyl-2',3'-dideoxyinosine(117312-02-4)
• EPA Substance Registry System: 5'-benzoyl-2',3'-dideoxyinosine(117312-02-4)

Safety Data

• Hazardous Substances Data: 117312-02-4(Hazardous Substances Data)

Upstream product

• 69655-05-6 Dideoxyinosine 
• 93-97-0 benzoic acid anhydride 

Relevant articles and documents

Prodrugs of 2',3'-dideoxyinosine (DDI): Improved oral bioavailability via hydrophobic esters

Five ester prodrugs of 2'3'-dideoxyinosine (DDI) were synthesized for the purpose of improving oral bioavailability. The prodrugs, acetate (C2-DDI), octanoate (C8-DDI), stearate (C18-DDI), benzoate (Bz-DDI), and hemisuccinate (Suc-DDI) were proved to quantitatively regenerate their parent drug by enzymatic hydrolysis. Though the chemical stability of the prodrugs under acidic conditions was not improved, their solubility in water was significantly decreased by esterification, except for Suc-DDI. Bioavailability was evaluated by oral administration to rats. Two hydrophobic prodrugs (C8-DDI and Bz-DDI) showed higher absolute bioavailability (23.5% and 31.0%, respectively) than did DDI (15.2%), though that of C2-DDI (11.5%) and Suc-DDI (4.5%) was poor.