1173196-86-5

Upstream product

• 50-00-0 formaldehyd 
• 108-91-8 cyclohexylamine 
• 62-53-3 aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant academic research and scientific papers

Magnetic Metal-Organic Framework CoFe2O4@SiO2@IRMOF-3 as an Efficient Catalyst for One-Pot Synthesis of Functionalized Dihydro-2-oxopyrroles

A magnetic metal-organic framework-based catalyst CoFe2O4@SiO2@IRMOF-3 was prepared and identified as an efficient catalyst for the synthesis of a variety of functionalized dihydro-2-oxopyrroles by a one-pot, four-component reaction of a dialkyl acetylenedicarboxylate, an aryl amine, formaldehyde, and optionally a second amine or diamine at room temperature. The catalyst was magnetically separated and recovered without significant loss of its catalytic efficiency, even after eight reaction cycles.

Nano Fe3O4 as a magnetically recyclable, powerful, and stable catalyst for the multi-component synthesis of highly functionalized dihydro-2-oxopyrroles

A mild and efficient method for the one-pot synthesis of functionalized dihydro-2-oxopyrroles is described via four-component domino reaction of amines, dialkyl acetylenedicarboxylates, and formaldehyde in the presence of super magnetic nano iron oxide (nano Fe3O4) in EtOH at room temperature. The major advantages of the present method are mild and green reaction conditions, high yields, short reaction times, clean reaction, magnetically recyclable catalyst, atom economy (63-76 %), operational simplicity, and no need for column chromatography. It is found that the catalyst is recyclable and can be used up to six times without significant loss of its activity.

One-pot four-component domino reaction for the synthesis of substituted dihydro-2-oxypyrrole catalyzed by molecular iodine

The synthesis of multi-functionalized dihydro-2-oxypyrrole can be achieved using one-pot four-component domino reaction from dialkylacetylene dicarboxylate, amines, and formaldehyde by employing molecular iodine as catalyst at room temperature. The salient features of the present method are: simple, straightforward, cost-effective, environmentally benign, and no column chromatographic separation is applicable on a broad range of substrates.

A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions

A series of tetra- and pentasubstituted polyfunctional dihydropyrroles 5 and 6 were synthesized via practical multicomponent reactions (MCRs) for research on their structure-activity relationship as caspase-3 inhibitors. Among 39 compounds evaluated, 14 of them exhibited inhibition against caspase-3 with IC50 ranging from 5 to 20 μM. The inhibitory activities of 5 and 6 depend on the nature of substituents on different positions. 5 and 6 possess a different scaffold from those previously reported and are the first caspase-3 inhibitors prepared via MCRs. The most active compounds 5k (IC50 = 5.27 μM) could therefore be used as a lead for the development of highly potent caspase-3 inhibitors as drug candidates for therapeutic agents by taking advantage of MCRs.