1173203-91-2Relevant academic research and scientific papers
Synthesis of benzodiazepines catalyzed by chitosan functionalized by triacid imide as a superior catalyst
Esfandiari, Mozhgan,Abbas, Ali Kareem,Vakili, Mohammad Reza,Shahbazi-Alavi, Hossein,Safaei-Ghomi, Javad
, p. 483 - 496 (2021)
Abstract: Chitosan functionalized by triacid imide has been applied as an effective catalyst for the synthesis of benzodiazepines by one-pot reactions of 1,2-phenylenediamine with dimedone and aryl aldehydes or isocyanides and Meldrum’s acid. Chitosan functionalized by triacid imide was confirmed by FT-IR (infrared spectroscopy), XRD (X-ray diffraction), DSC (differential scanning calorimetry) and TGA (thermogravimetric analysis). To investigate the scope and limitation of this reaction, different aryl aldehydes and isocyanides were used as substrates. Good yields in short reaction times, experimental simplicity, extensive range of products, retrieval of the catalyst and low catalyst loading are some of the substantial aspects of this method. Graphic abstract: [Figure not available: see fulltext.]
Synthesis of benzodiazepines catalyzed by CoFe2O4@SiO2-PrNH2 nanoparticles as a reusable catalyst
Miri, Naiereh Sadat,Safaei-Ghomi, Javad
, p. 497 - 503 (2017)
CoFe2O4@SiO2-PrNH2 nanoparticles have been used as an efficient catalyst for the preparation of benzodiazepines by multi-component reactions of 1,2-phenylenediamine, dimedone, different aldehydes or Meldrum's acid and isocyanides. This method provides several advantages including mild reaction conditions, the applicability to a wide range of substrates, the reusability of the catalyst and low catalyst loading.
Facile and efficient synthesis of benzo[b][1,5]diazepines by three-component coupling of aromatic diamines, Meldrum's acid, and isocyanides catalyzed by Fe3O4 nanoparticles
Ghasemzadeh, Mohammad Ali,Ghasemi-Seresht, Nasim
, p. 8625 - 8636 (2015/10/28)
Highly effective one-pot synthesis of benzo[b][1,5]diazepines has been achieved by three-component (or, in situ, including catalyst and solvent, five-component) reaction of aromatic diamines, Meldrum's acid, and isocyanides catalyzed by magnetite (Fe
A novel one-pot three-(in situ five-)component condensation reaction: an unexpected approach for the synthesis of tetrahydro-2,4-dioxo-1H-benzo[b][1,5] diazepine3-yl-2-methylpropanamide derivatives
Shaabani, Ahmad,Rezayan, Ali Hossein,Keshipour, Sajjad,Sarvary, Afshin,Ng, Seik Weng
supporting information; experimental part, p. 3342 - 3345 (2009/12/01)
A novel and efficient method has been developed for the synthesis of tetrahydro-2,4-dioxo-1H-benzo[b][1,5]diazepine-3-yl-2-methylpropanamide derivatives using an aromatic diamine, Meldrum's acid, and an isocyanide in CH2Cl2 at ambien
