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Upstream product

• 120-72-9 indole 
• 104-88-1 4-chlorobenzaldehyde 
• 100-61-8 N-methylaniline 
• 873-76-7 para-Chlorobenzyl alcohol 
• 66616-72-6 5-phenyl-1H-indole 

Relevant academic research and scientific papers

Iron mediated one pot three component synthesis of 3-substituted indoles via aerobic iminium ion formation

An efficient and economical method was developed for the synthesis of 3 substituted indoles by a highly efficient one-pot three component coupling reaction of substituted or unsubstituted benzyl alcohol, N-methyl aniline or pyrrolidine, and indoles or sub

Magnetically separable sulfonic acid catalysed one-pot synthesis of diverse indole derivatives

Fe3O4-OSO3H was identified as an efficient reusable catalyst for the facile synthesis of diarylmethyl indole derivatives under neat condition by C-C bond forming reaction. Fe3O4-OSO3H catal

One-pot Solvent Free Synthesis of Some Tert-indolylmethane Amine Derivatives by Fe(HSO4)3 as a Recyclable Catalyst

Solvent-free synthesis of 3-substituted indole derivatives by a one-pot three-component coupling reaction between aldehyde, N-alkyl aniline and indole by Fe(HSO4)3 catalyzed is described. The noticeable features of this protocol are

One-pot synthesis of 3-[(N-alkylanilino)(aryl)methyl]indoles via a transition metal assisted three-component condensation at room temperature

A simple and highly efficient protocol for the one-pot synthesis of a series of 3-[(N-alkylanilino)(aryl)methyl]indoles has been developed based on low-cost and environmentally benign zirconium oxychloride octahydrate and copper chloride dihydrate catalysts via three-component condensation between indoles, aromatic aldehydes, and N-alkylanilines at room temperature under neat condition. Mild reaction conditions, operational simplicity, high atom-economy, good yields in relatively shorter reaction times, use of low-cost and eco-friendly catalysts are some of the salient features of this protocol. A simple and highly efficient protocol for the one-pot synthesis of a series of 3-[(N-alkylanilino)(aryl)methyl]indoles has been developed based on low-cost and environmentally benign zirconium oxychloride octahydrate and copper chloride dihydrate catalysts via three-component condensation between indoles, aromatic aldehydes, and N-alkylanilines at room temperature under neat condition. Mild reaction conditions, operational simplicity, high atom-economy, good yields in relatively shorter reaction times, and use of low-cost and eco-friendly catalysts are the key advantages of the present protocol.

Catalyst-free, ethylene glycol promoted one-pot three component synthesis of 3-amino alkylated indoles via Mannich-type reaction Dedicated to Professor Richard A. Gibbs (1962-2014)

A highly efficient and sustainable approach for the multi-component synthesis of biologically important 3-amino alkylated indoles has been investigated via Mannich-type reaction under catalyst-free, ethylene glycol as a recyclable promoting medium. The wide applicability of the present method was examined with various substrates viz substituted aldehydes, indoles and secondary amines. This method will be useful for a large scale synthesis of 3-amino alkylated indoles without the use of column chromatography. The present method provides higher environmental compatibility and sustainability factors such as smaller E-factor (0.433) and higher atom-economy (AE = 93.3%).

CelluloseSulfonic acid: An efficient, recyclable, and biodegradable solid acid catalyst for the synthesis of 3-aminoalkylindoles

Three-component coupling (3CC) of indoles, aldehydes, and N-alkylanilines has been accomplished using a catalytic amount of cellulosesulfonic acid under mild reaction conditions to furnish the 3-aminoalkylindoles at room temperature in short reaction times and in relatively good to excellent yields and selectivity. The use of biodegradable cellulosesulfonic acid makes this method quite simple, convenient, and economically viable for the synthesis of 3-aminoalkylindoles.

Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water

An efficient micelle promoted one-pot synthesis of 3-amino alkylated indoles has been developed via a three-component Mannich-type reaction from secondary amines, aldehydes and indoles in water under mild reaction conditions. In this Mannich-type reaction

A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3-chlorophenylboronic acid as a catalyst under ambient temperature conditions. The three-component reaction of indoles, aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields. This protocol presents some remarkable features such as mild reaction conditions, simple workup procedure and excellent yields.

PANI-HBF4: A reusable polymer-based solid acid catalyst for three-component, one-pot synthesis of 3-substituted amino methyl indoles under solvent-free conditions

A simple, fast, efficient, high-yielding, and green process is developed for one-pot, three-component synthesis of 3-substituted amino methyl indoles under solvent-free conditions using polyaniline salt as polymer-based reusable solid acid catalyst at room temperature. The advantages of polyaniline salt catalyst are ease of synthesis and handling, low cost, versatality, and recyclability. Copyright Taylor & Francis Group, LLC.

3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities

An efficient and economical method was developed for the synthesis of 3-substituted indoles by one-pot three-component coupling reaction of a substituted or unsubstituted benzaldehyde, N-methylaniline, and indole or N-methylindole using Yb(OTf)3-SiO2 as a catalyst. All the synthesized compounds were evaluated for inhibition of cell proliferation of human colon carcinoma (HT-29), human ovarian adenocarcinoma (SK-OV-3), and c-Src kinase activity. The 4-methylphenyl (4o and 4p) and 4-methoxyphenyl (4q) indole derivatives inhibited the cell proliferation of SK-OV-3 and HT-29 cells by 70-77% at a concentration of 50 μM. The unsubstituted phenyl (4d) and 3-nitrophenyl (4l) derivatives showed the inhibition of c-Src kinase with IC50 values of 50.6 and 58.3 μM, respectively.