1173284-20-2

Upstream product

• 1968-72-5 methyl 6-amino-2,3,4-trimethoxy benzoate 
• 1752-00-7 methyl 2,3,4-trimethoxy-6-nitrobenzoate 
• 61948-84-3 2,3,4-trimethoxy-6-nitrobenzoic acid 
• 573-11-5 2,3,4-Trimethoxy-benzoic acid 
• 99-09-2 3-nitro-aniline 
• 55496-54-3 4-chloro-5,6,7-trimethoxyquinazoline 

Relevant academic research and scientific papers

Synthesis and anticancer activities of 5,6,7-trimethoxy-N-phenyl(ethyl)-4- aminoquinazoline derivatives

A series of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline compounds was prepared by microwave irradiation and conventional heating methods. Compounds 6p, 6q , and 6x strongly inhibited extracellular regulated kinas-1/2 (ERK1/2) phosphorylation induced by epidermal growth factor (EGF) at 1.28 μM in PC3 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that all compounds had certain anticancer activities, and the IC50 values of 6x were 6.2 ± 0.9, 3.2 ± 0.1, and 3.1 ± 0.1 μM against PC3, BGC823, and Bcap37 cells, respectively. Acridine orange/ethidium bromide staining, Hoechst 33258 staining, DNA ladder, and flow cytometry analyses revealed that 6x induced cell apoptosis in PC3 cells, with apoptosis ratios of 11.6% at 1 μM and 31.8% at 10 μM after 72 h.