117334-51-7

Upstream product

• 496048-65-8 (2S,4R)-2-(4-carbamoylthiazol-2-yl)-4-hydroxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 90822-24-5 (γR,2R,3S)-α-diazo-3-[(1R)-1-hydroxyethyl]-γ-methyl-β,4-dioxo-2-azetidinebutanoic acid (4-nitrophenyl)methyl ester 
• 117333-88-7 (2S,4S)-2-(4-carbamoylthiazol-2-yl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 496048-62-5 (2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 117336-97-7 (2S,4S)-4-acetylthio-2-(4-carbamoylthiazol-2-yl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 117336-90-0 (2S,4R)-2-(4-carbamoylthiazol-2-yl)-4-methanesulfonyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 496048-61-4 (2S,4R)-4-benzoyloxy-2-thiocarbamoyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives

The synthesis of a new series of 1β-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4′-amide substituted thiazole moiety showed the most potent antibacterial activity.

3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds

3-Pyrrolidinylthio-1-azabicyclo [320] hept-2-ene-2-carboxylic acid anti-microbiotic compounds are prepared.