1173435-69-2Relevant articles and documents
In vitro intrinsic clearance-based optimization of N3- phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists
Hartz, Richard A.,Ahuja, Vijay T.,Rafalski, Maria,Schmitz, William D.,Brenner, Allison B.,Denhart, Derek J.,Ditta, Jonathan L.,Deskus, Jeffrey A.,Yue, Eddy W.,Arvanitis, Argyrios G.,Lelas, Snjezana,Li, Yu-Wen,Molski, Thaddeus F.,Wong, Harvey,Grace, James E.,Lentz, Kimberley A.,Li, Jianqing,Lodge, Nicholas J.,Zaczek, Robert,Combs, Andrew P.,Olson, Richard E.,Mattson, Ronald J.,Bronson, Joanne J.,Macor, John E.
experimental part, p. 4161 - 4172 (2010/02/28)
A series of pyrazinone-based heterocycles was identified as potent and orally active corticotropinreleasing factor-1 (CRF1) receptor antagonists. Selected compounds proved efficacious in an anxiety model in rats; however, pharmacokinetic proper