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2-Hydroxysaclofen is a chemical compound that functions as a GABA-B receptor antagonist, primarily in the ventral tegmental area. It has been found to influence the mechanisms of cocaine usage and affect specific acute nicotine responses in mice.
Used in Pharmaceutical Applications:
2-Hydroxysaclofen is used as a GABA-B receptor antagonist for its potential role in understanding and treating substance abuse, particularly cocaine and nicotine addiction. It modulates the effects of these substances on the brain by targeting the GABA-B receptors, which are involved in the reward system and addictive behaviors.
Used in Research and Development:
In the field of neuroscience and pharmacology, 2-Hydroxysaclofen is used as a research tool to study the effects of GABA-B receptor modulation on various behaviors and responses, such as hypolocomotion and antinociception in mice. This helps researchers gain insights into the underlying mechanisms of addiction and potential therapeutic approaches.
Used in Drug Discovery and Development:
2-Hydroxysaclofen serves as a starting point for the development of new drugs targeting GABA-B receptors, which could potentially be used in the treatment of substance abuse disorders and other conditions related to the GABAergic system. Its unique properties make it a valuable compound for further research and drug design.

117354-64-0

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117354-64-0 Hazards Identification

Pictogram(s):

Signal:

Danger

GHS Hazard Statements:

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statement Codes:

P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories:

Skin Corr. 1B (100%)

117354-64-0 Usage

Biological Activity

Selective antagonist at GABA B receptors.

Check Digit Verification of cas no

The CAS Registry Mumber 117354-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,5 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117354-64:
(8*1)+(7*1)+(6*7)+(5*3)+(4*5)+(3*4)+(2*6)+(1*4)=120
120 % 10 = 0
So 117354-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)/t9-/m1/s1

117354-64-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid

1.2 Other means of identification

Product number -
Other names Dimaprit dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:117354-64-0 SDS

117354-64-0Downstream Products

117354-64-0Relevant academic research and scientific papers

The Synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen

Prager, Rolf H.,Schafer, Karl,Hamon, David P. G.,Massy-Westropp, Ralph A.

, p. 11465 - 11472 (2007/10/02)

2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABAB antagonist.

Potential GabaB Receptor Antagonists. V. The Application of Radical Additions to Styrenes to Produce 2-Hydroxysaclofen

Abbenante, Giovanni,Prager, Rolf H.

, p. 1791 - 1800 (2007/10/02)

3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid (2-hydroxysaclofen), and its 2-phenyl analogue have been synthesized by three methods.Two involve the oxygen-catalysed free radical addition of bisulfite to the corresponding 3-aminopropene or 3-pht

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