1173564-82-3

Basic information

• Product Name: 1-allyl-3-benzyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)urea
• Synonyms: 1-allyl-3-benzyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)urea
• CAS NO: 1173564-82-3
• Molecular Weight: 544.737
• Mol File: 1173564-82-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-allyl-3-benzyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-allyl-3-benzyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)urea(1173564-82-3)
• EPA Substance Registry System: 1-allyl-3-benzyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl)methyl)piperidin-4-yl)urea(1173564-82-3)

Safety Data

• Hazardous Substances Data: 1173564-82-3(Hazardous Substances Data)

Upstream product

• 934740-48-4 ((3R,4S)-4-((4-(allylamino)piperidin-1-yl)methyl)-3-hydroxy-3-phenylpyrrolidin-1-yl)(cyclopentyl)methanone 
• 41891-25-2 benzylaminocarbonyl chloride 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 100-46-9 benzylamine 

Relevant articles and documents

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents

A novel series of CCR5 antagonists has been identified, utilizing the lead, nifeviroc, which were further modified based on bioisosteric principles. Lead optimization was pursued by balancing potential toxicity and potency. Potent analogues with low toxic properties were successfully developed by formation of urea and amide bonds at the nitrogen at position 4- of the pyrrolidine ring.

PYROLLIDINE-BASED COMPOUNDS

The present invention discloses the compounds of formula ( I ) or a pharmaceutically acceptable derivative, salt or prodrug thereof, which can inhibit HIV replication.