117358-70-0

Upstream product

• 117358-61-9 10,10-dimethyl-7-(p-chlorophenyl)-7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one 
• 932748-12-4 C₂₅H₂₂ClNS 
• 126-81-8 dimedone 
• 134-32-7 1-amino-naphthalene 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Synthesis and spectral properties of 7-(p-bromophenyl)-10,10-dimethyl-8- alkylthio-7,9,10,11-tetrahydro-benz[c]acridines and deprotection-aromatization of 7-[(o-; and p-substituted)phenyl]-10,10-dimethyl-7,8,9,10,11,12- hexahydrobenz[c]acridin-8-thione

(Chemical Equation Presented) A series of sixteen new derivatives have been obtained and all have potentially useful pharmacological activity. The treatment of 7-[(o-chloro and p-bromo)phenyl]-7,8,9,10,11,12-hexahydrobenz[c] acridin-8-one and Lawesson's reagent obtains the corresponding 7-[(o- and p-substituted)phenyl]-10,10-dimethyl-7,8,9,10,11,12-hexahydrobenz[c] acridin-8-thione II which was alkylated in presence of sodium hydride and the corresponding alkyl iodide under nitrogen atmosphere to obtain 8-alkylthio-7,9,10,11-tetrahydro-benz[c]acridines III, 1-4. The thione II was desprotected and aromatized in presence of sodium hydride in absence of nitrogen atmosphere to produce a mixture of 7-[(o- and p-substituted)phenyl]-10,10- dimethyl-8,9,10,11-tetrahydrobenz[c]-acridin-8-one IV, 1-6 and 7-[(o- and p-substituted)phenyl]-10,10-dimethyl-8-hydroxi-8,9,10,11-tetrahydrobenz[c] acridine V, 1-6. The structure of all products was corroborated by ir, 1H NMR, 13C NMR with bidimensional experiments and ms with CID experiments.

Synthesis and Spectra of 7-(o- and p-R-Phenyl)-10,10-dimethyl-8,9,10,11-tetrahydrobenzacridin-8-ones. Structure Correction of 1,2,3,4-Tetrahydro-2,2-dimethyl-5-aryl-6-aza-7,8-benzophenanthren-4-ones

It has been reported that dimedone added to α-arylidennaphthylamines in ethanol with formation of 1,4-addition products derivatives of 5-aryl-5,6,7,8,9,10-hexahydrobenzophenanthridin-7-ones, III, which are easily oxidized by chromic anhydride to the co