117359-33-8Relevant academic research and scientific papers
Acyclic Analogs of Nucleosides. Synthesis of 1,5-Dihydroxy-3-oxa-2-pentyl Derivatives of Nucleic Bases
Zavgorodnii, S. G.,Efimtseva, E. V.,Mikhailov, S. N.,Tsilevich, T. L.,Yavorskii, A. E.,Florent'ev, V. L.
, p. 186 - 191 (1988)
A convenient method for the synthesis of 1,5-dihydroxy-3-oxa-2-pentyl derivatives of nucleic bases, which consists in the condensation of trimethylsilyl derivatives of nucleic bases with 1,2,5-triacetoxy-3-oxapentane in the presence of SnCl4, is proposed.Optically active derivatives - (R)- and (S)-1-(1,5-dihydroxy-3-oxa-2-pentyl)uracil, respectively - were obtained by periodate oxidation of α-L- and α-D-arabinopyranosyluracil.
