1173657-04-9Relevant articles and documents
A highly effective synthesis of 2-alkynyl-7-azaindoles: Pd/C-mediated alkynylation of heteroaryl halides in water
Layek, Mohosin,Gajare, Vikas,Kalita, Dipak,Islam, Aminul,Mukkanti,Pal, Manojit
experimental part, p. 4814 - 4819 (2009/10/02)
The reaction of 4-chloro-2-iodo-7-azaindole with terminal alkynes was investigated using 10% Pd/C-PPh3-CuI as a catalyst system in water. This study afforded a new, mild and selective process for the preparation of 2-alkynyl-4-chloro-7-azaindole in good yields via C-C bond forming reaction. The resulting chloro derivative can be functionalized further via another Pd-mediated C-C bond forming reaction?with arylboronic acid.