117369-94-5

Basic information

• Product Name: Methyl 2-hydroxy-4-phenylbenzoate
• Synonyms: Methyl 2-hydroxy-4-phenylbenzoate
• CAS NO: 117369-94-5
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24328
• Mol File: 117369-94-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-hydroxy-4-phenylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-hydroxy-4-phenylbenzoate(117369-94-5)
• EPA Substance Registry System: Methyl 2-hydroxy-4-phenylbenzoate(117369-94-5)

Safety Data

• Hazardous Substances Data: 117369-94-5(Hazardous Substances Data)

Usage

General Description

Methyl 2-hydroxy-4-phenylbenzoate is a chemical compound with the molecular formula C14H12O3. It is an ester, formed by the condensation of 2-hydroxy-4-phenylbenzoic acid and methanol. Methyl 2-hydroxy-4-phenylbenzoate is commonly used in the production of fragrances, flavors, and pharmaceuticals due to its aromatic properties. It is also used as an intermediate in the synthesis of various organic compounds. Methyl 2-hydroxy-4-phenylbenzoate is a white crystalline solid with a slight odor, and it is soluble in organic solvents such as ethanol and acetone. It is important to handle this compound with care and follow proper safety measures, as it may cause skin and eye irritation.

Upstream product

• 4482-27-3 3-hydroxy-[1,1'-biphenyl]-4-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 175152-70-2 methyl 3-methoxy-[1,1‘-biphenyl]-4-carboxylate 
• 98-80-6 phenylboronic acid 
• 139102-34-4 methyl 4-bromo-2-methoxybenzoate 
• 22717-56-2 4-bromo-2-Hydroxybenzoic Acid Methylester 
• 88681-86-1 3-Oxo-5-phenyl-hept-6-enoic acid methyl ester 

Downstream Products

• 4482-27-3 3-hydroxy-[1,1'-biphenyl]-4-carboxylic acid 
• 63906-80-9 3-(2-hydroxy-ethoxy)-biphenyl-4-carboxylic acid methylamide 

Relevant articles and documents

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials

The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for prevention and treatment of malaria. Previously, we described a novel antimalarial acridone chemotype that is potent against both blood-stage and liver-stage malaria parasites. Here, we describe an optimization process that has produced a second-generation acridone series with significant improvements in efficacy, metabolic stability, pharmacokinetics, and safety profiles. These findings highlight the therapeutic potential of dual-stage targeting acridones as novel drug candidates for further preclinical development.

ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

Apoptosis is regulated by the BCL-2 family of proteins, which is comprised of both pro-death and pro-survival members. Evasion of apoptosis is a hallmark of malignant cells. One way in which cancer cells achieve this evasion is thru overexpression of the pro-survival members of the BCL-2 family. Overexpression of MCL-1, a pro-survival protein, has been shown to be a resistance factor for Navitoclax, a potent inhibitor of BCL-2 and BCL-XL. Here we describe the use of fragment screening methods and structural biology to drive the discovery of novel MCL-1 inhibitors from two distinct structural classes. Specifically, cores derived from a biphenyl sulfonamide and salicylic acid were uncovered in an NMR-based fragment screen and elaborated using high throughput analog synthesis. This culminated in the discovery of selective and potent inhibitors of MCL-1 that may serve as promising leads for medicinal chemistry optimization efforts.