1173698-63-9

Basic information

• Product Name: 6-[2-(4-chlorophenyl)vinyl]-5-nitro-2,4(1H,3H)-pyrimidinedione
• Synonyms: 6-[2-(4-chlorophenyl)vinyl]-5-nitro-2,4(1H,3H)-pyrimidinedione
• CAS NO: 1173698-63-9
• Molecular Formula: C12H8ClN3O4
• Molecular Weight: 293.66262
• Mol File: 1173698-63-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-[2-(4-chlorophenyl)vinyl]-5-nitro-2,4(1H,3H)-pyrimidinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[2-(4-chlorophenyl)vinyl]-5-nitro-2,4(1H,3H)-pyrimidinedione(1173698-63-9)
• EPA Substance Registry System: 6-[2-(4-chlorophenyl)vinyl]-5-nitro-2,4(1H,3H)-pyrimidinedione(1173698-63-9)

Safety Data

• Hazardous Substances Data: 1173698-63-9(Hazardous Substances Data)

Upstream product

• 16632-21-6 5-nitro-6-methyluracil 
• 104-88-1 4-chlorobenzaldehyde 
• 626-48-2 6-Methyluracil 

Relevant articles and documents

Synthesis and biological evaluation of 5-nitropyrimidine-2,4-dione analogues as inhibitors of nitric oxide and iNOS activity

Fifty two compounds based on 5-nitropyrimidine-2,4-dione moiety have been synthesized and evaluated for their inhibitory potency on the production of nitric oxide. Among them, compound 36 inhibited the production of nitric oxide (IC50: 8.6 μM) on lipopolysaccharide-induced RAW 264.7 cells and inducible nitric oxide synthase activity (IC50: 6.2 μM), as well as exerted no potential cytotoxicity (IC50 > 80.0 μM). Docking study confirmed that compound 36 was an inducible nitric oxide synthase inhibitor with perfect binding to the active site of inducible nitric oxide synthase. At a dose of 10 mg/kg, oral administration of 36 possessed protective properties in carrageenan-induced paw edema of male ICR mice.