117376-86-0Relevant academic research and scientific papers
Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors
Varaprasad, Chamakura V.N.S.,Barawkar, Dinesh,Abdellaoui, Hassan El,Chakravarty, Subrata,Allan, Matthew,Chen, Huanming,Zhang, Weijian,Wu, Jim Z.,Tam, Robert,Hamatake, Robert,Lang, Stanley,Hong, Zhi
, p. 3975 - 3980 (2007/10/03)
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.
A Facile Synthesis of 3-Amino-5-substitutedaminoisothiazole-4-carboxylic Acid Derivatives
Shishoo, C. J.,Devani, M. B.,Ananthan, S.,Bhadti, V. S.,Ullas, G. V.
, p. 759 - 765 (2007/10/02)
A facile, general and one-pot method for the preparation of 3-amino-5-substituted-aminoisothiazole-4-carboxylic acid derivatives, in high yields, by the aminative cyclization of 3-amino-3-mercaptoacrylonitriles is described.
