117377-43-2

Basic information

• Product Name: 3-amino-5-(phenylamino)-1,2-thiazole-4-carbonitrile
• CAS NO: 117377-43-2
• Molecular Formula: C₁₀H₈N₄S
• Molecular Weight: 216.2623
• Mol File: 117377-43-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 326.849°C at 760 mmHg
• Flash Point: 151.473°C
• Density: 1.402g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.694
• CAS DataBase Reference: 3-amino-5-(phenylamino)-1,2-thiazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-5-(phenylamino)-1,2-thiazole-4-carbonitrile(117377-43-2)
• EPA Substance Registry System: 3-amino-5-(phenylamino)-1,2-thiazole-4-carbonitrile(117377-43-2)

Safety Data

• Hazardous Substances Data: 117377-43-2(Hazardous Substances Data)

Upstream product

• 61108-12-1 sodium 2,2-dicyano-1-(phenylamino)ethene-1-thiolate 
• 103-72-0 phenyl isothiocyanate 
• 109-77-3 malononitrile 
• 17823-65-3 2-cyano-3-methylthio-3-phenylaminoacrylonitrile 

Downstream Products

• 117376-88-2 3-amino-5-(phenylamino)isothiazole-4-carboxamide 

Relevant articles and documents

Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine

Various derivatives of 5-aryl-4-imino-3-(phenylamino)-4,5-dihydroisothiazolo[3,4-d]pyrimidines (3a-f) were synthesized. The synthesis has been done through treatment of 3-amino-4-cyano-5-(phenylamino)isothiazole with various aryl isothiocyanates. The isothiazole skeleton was obtained by the reaction of malononitrile and phenyl isothiocyanate followed by chloramine treatment. Some of the synthesized dihydroisothiazolo[3,4-d]pyrimidines were tested against different cancer cell lines, including ACHN, HeLa, HL-60, MCF-7, and PC3. Malignant cells were cultured in RPMI medium and incubated with different concentrations of the mentioned compounds. Cell viability was assessed using the MTS assay. The cytotoxicities of the synthesized compounds are not significant and are probably safe for other biological use.

A Facile Synthesis of 3-Amino-5-substitutedaminoisothiazole-4-carboxylic Acid Derivatives

A facile, general and one-pot method for the preparation of 3-amino-5-substituted-aminoisothiazole-4-carboxylic acid derivatives, in high yields, by the aminative cyclization of 3-amino-3-mercaptoacrylonitriles is described.