117377-43-2Relevant academic research and scientific papers
Synthesis and antiproliferative assessments of new derivatives of isothiazolo[3,4-d]pyrimidine
Khoshniazi, Hamideh,Eshghi, Hossein,Tayarani-Najjaran, Mona,Tayarani-Najaran, Zahra,Saadat, Kayvan,Shiri, Ali
, p. 193 - 201 (2020/11/12)
Various derivatives of 5-aryl-4-imino-3-(phenylamino)-4,5-dihydroisothiazolo[3,4-d]pyrimidines (3a-f) were synthesized. The synthesis has been done through treatment of 3-amino-4-cyano-5-(phenylamino)isothiazole with various aryl isothiocyanates. The isothiazole skeleton was obtained by the reaction of malononitrile and phenyl isothiocyanate followed by chloramine treatment. Some of the synthesized dihydroisothiazolo[3,4-d]pyrimidines were tested against different cancer cell lines, including ACHN, HeLa, HL-60, MCF-7, and PC3. Malignant cells were cultured in RPMI medium and incubated with different concentrations of the mentioned compounds. Cell viability was assessed using the MTS assay. The cytotoxicities of the synthesized compounds are not significant and are probably safe for other biological use.
Heterocyclic compounds and uses thereof
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Page/Page column 10, (2008/06/13)
Substituted isothiazole compounds and compositions are provided, wherein particularly preferred compositions and methods are directed towards inhibition of various protein kinases (especially MEK and/or ERK). Consequently, particularly preferred methods i
A Facile Synthesis of 3-Amino-5-substitutedaminoisothiazole-4-carboxylic Acid Derivatives
Shishoo, C. J.,Devani, M. B.,Ananthan, S.,Bhadti, V. S.,Ullas, G. V.
, p. 759 - 765 (2007/10/02)
A facile, general and one-pot method for the preparation of 3-amino-5-substituted-aminoisothiazole-4-carboxylic acid derivatives, in high yields, by the aminative cyclization of 3-amino-3-mercaptoacrylonitriles is described.
