1173794-86-9Relevant academic research and scientific papers
Diclofenac derivatives with insulin-sensitizing activity
Wang, Jian Ta,Wang, Ying,Zhang, Ji Quan,Cui, Xing,Zhang, Yi,Zhu, Gao Feng,Tang, Lei
, p. 409 - 412 (2012/01/06)
A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone.
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives
Zhang, Jiquan,Wang, Jianta,Wu, Haoshu,He, Yaoyao,Zhu, Gaofeng,Cui, Xing,Tang, Lei
scheme or table, p. 3324 - 3327 (2010/03/31)
A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARγ agonist, or improved insulin resistance through non-PPARγ pathway.
