1173883-05-0

Basic information

• Product Name: 3-(3-fluorophenyl)isoquinoline
• Synonyms: 3-(3-fluorophenyl)isoquinoline
• CAS NO: 1173883-05-0
• Molecular Weight: 223.25
• Mol File: 1173883-05-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(3-fluorophenyl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluorophenyl)isoquinoline(1173883-05-0)
• EPA Substance Registry System: 3-(3-fluorophenyl)isoquinoline(1173883-05-0)

Safety Data

• Hazardous Substances Data: 1173883-05-0(Hazardous Substances Data)

Upstream product

• 1173882-92-2 2-[2-(3-fluorophenyl)-1-ethynyl]benzaldehyde 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 50624-28-7 1-(isoquinolin-2(1H)-yl)ethan-1-one 
• 768-35-4 3-fluorophenylboronic acid 
• 643-79-8 o-phthalic dicarboxaldehyde 

Relevant articles and documents

NHC-Mediated Stetter-Aldol and Imino-Stetter-Aldol Domino Cyclization to Naphthalen-1(2 H)-ones and Isoquinolines

N-Heterocyclic carbene-catalyzed tandem Stetter-aldol reaction of phthalaldehyde and α,β-unsaturated ketimines has been developed to afford functionalized naphthalen-1(2H)-one derivatives as the formal [4+2] annulation product. Interestingly, the reaction of aldimines led to the formation of isoquinoline derivatives instead of the expected indanone derivatives as a [4+1] annulation product.

One substrate, two modes of C-H functionalization: A metal-controlled site-selectivity switch in C-H arylation reactions

A unique site-selectivity switch has been achieved in the ruthenium-catalyzed C-H arylation reaction of N-acetyl-1,2-dihydroisoquinolines. This metal-mediated switch is antipodal to the previous report on the palladium-mediated C-4 C-H arylation on the same substrate. Mechanistic details reveal interesting aspects of the reaction pathway, and kinetic studies bring out the difference in the modes of C-H activation adopted by the two catalytic systems.

Palladium-catalyzed, microwave-enhanced three-component synthesis of isoquinolines with aqueous ammonia

A variety of substituted isoquinoline derivatives can be synthesized in moderate yield by a palladium-catalyzed, microwave-assisted MCR starting from o-bromoarylaldehydes, terminal alkynes, and aqueous ammonia. Georg Thieme Verlag Stuttgart New York.

Microwave-promoted synthesis of N-heterocycles by tandem imination/ annulation of γ- and δ-ketoalkynes in the presence of ammonia

The synthesis of 3-substituted l-methylpyrrolo[l,2-a]pyrazines and 3-substituted isoquinolines was achieved by the intramolecular cyclisation of 2-acetyl-l-propargylpyrroles and 2-alkynylbenzaldehydes, respectively, in the presence of ammonia under microwave heating. The tandem imination/annulation of 2-alkynylbenzaldehydes was easily accomplished under standard conditions, while TiCl4 was used to achieve pyrrolo[l,2-a]pyrazines. The reaction mechanism and the regioselectivity were discussed on the basis of theoretical calculations and spectroscopic data. Wiley-VCH Verlag GmbH & Co. KGaA.