1173884-62-2Relevant academic research and scientific papers
Asymmetric aminolytic kinetic resolution of racemic epoxides using recyclable chiral polymeric Co(III)-salen complexes: A protocol for total utilization of racemic epoxide in the synthesis of (R)-naftopidil and (S)-propranolol
Kumar, Manish,Kureshy, Rukhsana I.,Shah, Arpan K.,Das, Anjan,Khan, Noor-Ul H.,Abdi, Sayed H. R.,Bajaj, Hari C.
, p. 9076 - 9084 (2013/10/08)
Chiral polymeric Co(III) salen complexes with chiral ((R)/(S)-BINOL, diethyl tartrate) and achiral (piperazine and trigol) linkers with varying stereogenic centers were synthesized for the first time and used as catalysts for aminolytic kinetic resolution (AKR) of a variety of terminal epoxides and glycidyl ethers to get enantio-pure epoxides (ee, 99%) and N-protected β-amino alcohols (ee, 99%) with quantitative yield in 16 h at RT under optimized reaction conditions. This protocol was also used for the synthesis of two enantiomerically pure drug molecules (R)-Naftopidil (α1- blocker) and (S)-Propranolol (β-blocker) as a key step via AKR of single racemic naphthylglycidyl ether with Boc-protected isoproylamine with 100% epoxide utilization at 1 g level. The catalyst 1 was successfully recycled for a number of times.
Highly efficient recyclable CoIII-salen complexes in the catalyzed asymmetric aminolytic kinetic resolution of aryloxy/terminal epoxides for the simultaneous production of N-protected 1,2-amino alcohols and the corresponding epoxides in high op
Kureshy, Rukhsana I.,Prathap, K. Jeya,Agrawal, Santosh,Kumar, Manish,Khan, Noor-Ul H.,Abdi, Sayed H. R.,Bajaj, Hari C.
supporting information; experimental part, p. 2863 - 2871 (2009/09/29)
Chiral CoIII-salen complexes 1-6 bearing different substituents at the 3,3′- and 5,5′-positions of the salen unit, namely H, tBu, morpholmomethyl, and piperidinomethyl, have been synthesized. These complexes were used as catalysts in an environ
