1173884-70-2Relevant academic research and scientific papers
Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo
Beans, Elizabeth J.,Fournogerakis, Dennis,Gauntlett, Carolyn,Heumann, Lars V.,Kramer, Rainer,Marsden, Matthew D.,Murray, Danielle,Chun, Tae-Wook,Zack, Jerome A.,Wender, Paul A.
, p. 11698 - 11703 (2013/08/23)
Highly active antiretroviral therapy (HAART) decreases plasma viremia belowthe limits of detection in the majority of HIV-infected individuals, thus serving to slow disease progression. However, HAART targets only actively replicating virus and is unable
Process to Produce Prostratin and Structural or Functional Analogs Thereof
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Page/Page column 9-10; 13-14; 20; 24; 25, (2009/07/25)
This invention concerns a process to convert a hydroxyl group (bold in R3C—OH) in a tigliane-type compound to a hydrogen (bold in R3C—H) to obtain deoxytigliane-type compounds or structural or functional analogs thereof. The process has wide application particularly to produce specific biologically active compounds in quantity for use as pharmaceuticals. In particular the process can be used to convert phorbol to a 12-deoxytigliane (prostrating which is a therapeutic lead for the treatment of AIDS. New compositions of matter are also disclosed.
